Evaluation of the Nephroprotective Effect of Omega-3 Polyunsaturated Fatty Acids on Gentamicin-Induced Renal Toxicity in Albino Wistar Rats

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By Research Archive Posted on Jan 2, 2023
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Ahon Gnamien Marcel, Ouattara Sitapha, Djyh Bernard Nazaire, Lago Gnonseka Constantin Mederic, Yapi Houphouet Felix, Djaman Allico Joseph American Journal of BioScience (Science Publishing Group) 2022
English Ivory Coast
Abstract
The kidney performs several important functions in the body. Its failure leads to a dysfunction that deserves a solution. Thus, this study was initiated to investigate the protective effects of omega-3 fatty acids on nephrotoxicity. For this purpose, 48 Albino Wistar rats (male and female) were divided into 8 groups of 6 rats. The first group, serving as a control, received 1 mL/g body weight of distilled water daily by gavage and a 0.9% NaCl solution intraperitoneally one hour later. The second, received gentamicin at a dose of 80 mg/Kg/day by intraperitoneal injection for 7 days, the third, treated with the combination of omega 3 by gavage at a dose of 200 mg/Kg of body weight plus gentamicin by intraperitoneal injection at a dose of 80 mg/Kg for the same period. The fourth, treated with the combination of omega 3 by gavage at a dose of 600 mg/Kg body weight plus gentamycin by intraperitoneal injection at a dose of 80 mg/Kg for 7 days, the fifth, treated with the combination of vitamin E at a dose of 250 mg/kg/day body weight by gavage plus gentamicin by intraperitoneal injection at a dose of 80 mg/Kg for 7 days. The sixth and seventh received 200 mg/kg and 600 mg/kg body weight by gavage of omega-3 for 7 days, respectively. The last group received vitamin E at a dose of 250 mg/kg/day of body weight by gavage. Omega-3 at a dose of 600 mg/kg body weight exerts a protective effect against induced nephrotoxicity in rats (especially females), with a decrease in urea and creatinine levels. The consumption of food rich in omega 3 in the protection of the kidneys advised. Further studies could be envisaged to compare the protective effects of omega-3 with other polyunsaturated fatty acids (omega-6 and 9) on nephrotoxicity.
Gentamicin, Nephrotoxicity, Kidney, Omega-3

The kidney performs several important functions in the body. Its failure leads to a dysfunction that deserves a solution. Thus, this study was initiated to investigate the protective effects of omega-3 fatty acids on nephrotoxicity. For this purpose, 48 Albino Wistar rats (male and female) were divided into 8 groups of 6 rats. The first group, serving as a control, received 1 mL/g body weight of distilled water daily by gavage and a 0.9% NaCl solution intraperitoneally one hour later. The second, received gentamicin at a dose of 80 mg/Kg/day by intraperitoneal injection for 7 days, the third, treated with the combination of omega 3 by gavage at a dose of 200 mg/Kg of body weight plus gentamicin by intraperitoneal injection at a dose of 80 mg/Kg for the same period. The fourth, treated with the combination of omega 3 by gavage at a dose of 600 mg/Kg body weight plus gentamycin by intraperitoneal injection at a dose of 80 mg/Kg for 7 days, the fifth, treated with the combination of vitamin E at a dose of 250 mg/kg/day body weight by gavage plus gentamicin by intraperitoneal injection at a dose of 80 mg/Kg for 7 days. The sixth and seventh received 200 mg/kg and 600 mg/kg body weight by gavage of omega-3 for 7 days, respectively. The last group received vitamin E at a dose of 250 mg/kg/day of body weight by gavage. Omega-3 at a dose of 600 mg/kg body weight exerts a protective effect against induced nephrotoxicity in rats (especially females), with a decrease in urea and creatinine levels. The consumption of food rich in omega 3 in the protection of the kidneys advised. Further studies could be envisaged to compare the protective effects of omega-3 with other polyunsaturated fatty acids (omega-6 and 9) on nephrotoxicity.

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