Predicting the Severity of COVID-19 Pneumonia in Children

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By Research Archive Posted on Jan 6, 2023
In Category - Research
Huseynova Ilhama Yelmar, Hasanov Alekber Qazanfar, Gafarov Ismayil Adil American Journal of Biomedical and Life Sciences (Science Publishing Group) 2022
English Azerbaijan
Abstract
Today, the relationship between cytokines in blood serum and the pathogenesis of the disease during COVID-19 in children has not yet been fully clarified. Research shows that the course of the disease in children is more satisfactory than in adults. However, the clinical profiles and pathophysiology of COVID-19 in children remain unclear. The aim of our study was to determine the level of cytokines in children with COVID-19 pneumonia and to study their role in predicting the severity of the disease. For this purpose, 75 children under the age of 18 were included. The patients included in the study were divided into 2 groups according to the degree of severity: 49 (65.3%) moderately severe patients with COVID-19 pneumonia were included in group I, and 26 (34.7%) patients with severe COVID-19 pneumonia were included in group II. Clinical, instrumental and laboratory examinations, determination of cytokines IL-1β, IL-6, IL-18, vitamin D, fibrinogen, ferritin and D-dimer levels were included in the examination methods of patients. Fever (66 cases (88.0%)) and cough (74 cases (98.7%)) were the most frequently reported cases. Laboratory examinations of blood in children with COVID-19 (PCR) showed a tendency to lymphocytosis and thrombocytopenia, an increase in ESR, CRP, ferritin, D-dimer, fibrinogen, and cytokines levels. In comparison between groups, the levels of IL-1β, IL-6, IL-18 increased in group II compared to group I. Determination of pro-inflammatory cytokines IL-1β, IL-6, IL-18 in children with COVID-19 (PCR), depending on the severity of the disease, is appropriate for early diagnosis and prediction of the course of the disease.
Children, COVID-19, Cytokine Profile, Prognosis

Today, the relationship between cytokines in blood serum and the pathogenesis of the disease during COVID-19 in children has not yet been fully clarified. Research shows that the course of the disease in children is more satisfactory than in adults. However, the clinical profiles and pathophysiology of COVID-19 in children remain unclear. The aim of our study was to determine the level of cytokines in children with COVID-19 pneumonia and to study their role in predicting the severity of the disease. For this purpose, 75 children under the age of 18 were included. The patients included in the study were divided into 2 groups according to the degree of severity: 49 (65.3%) moderately severe patients with COVID-19 pneumonia were included in group I, and 26 (34.7%) patients with severe COVID-19 pneumonia were included in group II. Clinical, instrumental and laboratory examinations, determination of cytokines IL-1β, IL-6, IL-18, vitamin D, fibrinogen, ferritin and D-dimer levels were included in the examination methods of patients. Fever (66 cases (88.0%)) and cough (74 cases (98.7%)) were the most frequently reported cases. Laboratory examinations of blood in children with COVID-19 (PCR) showed a tendency to lymphocytosis and thrombocytopenia, an increase in ESR, CRP, ferritin, D-dimer, fibrinogen, and cytokines levels. In comparison between groups, the levels of IL-1β, IL-6, IL-18 increased in group II compared to group I. Determination of pro-inflammatory cytokines IL-1β, IL-6, IL-18 in children with COVID-19 (PCR), depending on the severity of the disease, is appropriate for early diagnosis and prediction of the course of the disease.

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